Franklin IC-168 Bedienungsanleitung

FOLD

User’s Manual

HANDBOOK

ADVERSE

DRUG

INTERACTIONS

The Medical Letter



DIGITAL BOOK

IC-168



Electronic Publishers

For Use with the Franklin

Digital Book System



Electronic Publishers



READ THIS LICENSE AGREEMENT BEFORE USING THE

DIGITAL BOOK. YOUR USE OF THE DIGITAL BOOK DEEMS

THAT YOU ACCEPT THE TERMS OF THIS LICENSE. IF YOU

DO NOT AGREE WITH THESE TERMS, YOU MAY RETURN

THIS PACKAGE WITH PURCHASE RECEIPT TO THE DEALER

FROM WHICH YOU PURCHASED THE DIGITAL BOOK AND

YOUR PURCHASE PRICE WILL BE REFUNDED. DIGITAL BOOK

means the software product and documentation found in this

package and FRANKLIN means Franklin Electronic Publishers, Inc.

LIMITED USE LICENSE

All rights in the DIGITAL BOOK remain the property of FRANKLIN.

Through your purchase, FRANKLIN grants you a personal and

nonexclusive license to use the DIGITAL BOOK on a single

FRANKLIN Digital Book System at a time. You may not make any

copies of the DIGITAL BOOK or of the data stored therein, whether

in electronic or print format. Such copying would be in violation of

applicable copyright laws. Further, you may not modify, adapt,

disassemble, decompile, translate, create derivative works of, or in

any way reverse engineer the DIGITAL BOOK. You may not export

or reexport, directly or indirectly, the DIGITAL BOOK without

compliance with appropriate governmental regulations. The

DIGITAL BOOK contains Franklin’s confidential and propriety

information which you agree to take adequate steps to protect from

unauthorized disclosure or use. This license is effective until

terminated. This license terminates immediately without notice from

FRANKLIN if you fail to comply with any provision of this license.

This digital book was developed for use by medical professionals.

No other use of this digital book can substitute for consultation with

yourphysician.

LicenseAgreement

Contents

Introduction to the HADI...................................3

Overview of Operation......................................5

Installing the Digital Book ................................7

Viewing a Demonstration .................................9

Selecting Drugs................................................10

Correcting Misspellings ..................................12

Finding Brands, Generics, Groups ................14

Finding Interactions........................................ 16

Between Many Drugs ..................................16

For a Single Drug........................................ 18

Viewing References ........................................ 20

Sending Words to Other Books..................... 22

Digital Book System®.......................................23

Limited Warranty............................................. 25

Product Specifications ................................... 26

Key Guide .........................................................27

Index..................................................................30

This handbook offers a quick guide to possible adverse effects

of drug interactions, with brief recommendations for precaution-

ary measures. References are given to original reports that

provide more complete discussions of each interaction.

This book— lists adverse drug interactions, their mechanisms,

and recommendations for clinical management. These listings

are usually based on clinical reports.

Reports of interactions between more than two drugs are

appearing in the medical literature with increasing frequency.

Where these have been documented, they are noted as

comments under interacting pairs of drugs. Interactions listed

for groups of drugs (such as “cephalosporins” or “antidepres-

sants, tricyclic”) may not have been reported for every drug in

the group; known exceptions to the interaction are noted.

It is not possible to determine the frequency of most interac-

tions. When an interaction is documented by one or two case

reports rather than by clinical studies or reports in many

patients, the year of each report is given as some indication of

frequency.

Omissions—New adverse interactions are continually being

reported; the absence of a listing in this digital book does not

necessarily mean that drugs will not interact when given

concurrently. Drugs for which we have no documented

interactions in people are usually not listed; interactions

extrapolated from animal studies or interactions reported

with related drugs, frequently mentioned in other sources,

such as the manufacturer’s package insert, may therefore

not be included here.

Interactions between general anesthetics and drugs likely to be

administered during surgery, such as autonomic drugs and

Introduction to the HADI

local anesthetics, are not included here. Interactions useful in

therapy, such as increased plasma concentration of penicillin

with concurrent use of probenecid, are also not included.

Common additive effects, such as occur with use of two

antihypertensive agents or two central nervous system

depressants, are generally not listed. Effects expected from the

mechanism of a drug’s action, such as that of potassium on

digitalis glycosides or calcium on calcium-entry blockers, and

useful antagonist effects, such as that between a poison and an

antidote, are also not included. Most interactions of drugs with

foods, beverages, or other nutrients are not listed, but foods

interacting with monoamine oxidase inhibitors are included.

Mechanisms of Interaction—Genetic differences can affect

drug metabolism and interactions. Drugs can interact by

changing the metabolism of other drugs, either through

inhibition or induction of any of several hepatic enzyme

activities or through alterations in hepatic blood flow; by altering

the binding of other drugs to plasma proteins or tissue

receptors; by altering the distribution of drugs to active receptor

sites; by delaying or enhancing excretion; or by causing additive

or synergistic effects.

Recommendations—Monitoring is most important when one of

the interacting drugs is stopped or started. Some experienced

clinicians may prefer to monitor the patient’s clinical status

rather than follow serum concentrations of drugs. Concurrent

use of drugs from the same group, e.g., aspirin and other

NSAIDS, should be avoided.

Overview of Operation

What this

HADI

Can Do

The Medical Letter®Handbook of Adverse Drug

Interactions

is a powerful reference. Using this

digital book, you can. . .

• find brand name drugs, generic drugs, drug

groups, and food groups,

• correct drug name misspellings,

• find foods that interact with MAO inhibitors,

• select up to 20 drugs and view a list of their

interactions,

• select a single drug and view a list of the drugs

with which it interacts,

• read descriptions and references about drug

interactions, and

• look up drugs and words in related digital books.

Read this User’s Manual to learn how.

▼

How this

HADI

Works

The

Handbook

is easy to use. Here are the basics:

Highlight the HADI symbol and press

ENTER

• At the main drug list, As you type, the drug

type a drug name. name is highlighted.

Then press

ENTER

• Type another drug You see a message to

name. Press

ENTER

✻

SHOW INTERACTIONS

✻

• Press

ENTER

.You see the interactions,

if any, between the drugs.

• Press

ENTER

.You see a description of

the interaction.

• Press

CLEAR

.You’re ready to find

other interactions.

Overview of Operation

✓About the Screen Illustrations

Some screen illustrations in this User’s Manual

may vary slightly from what you see on screen.

These variations do not mean that this digital

book or your Digital Book System is malfunctioning.

▼

Before you can use this digital book, you must install

it. Warning: If you install a digital book

while the

Digital Book System is on, information that you en-

tered in other currently installed digital books may be

erased.

1. Turn the Digital Book System off.

2. Install the digital book into a slot on the

back of the Digital Book System.

Align the tabs on the digital book with the notches

in the slot. Make sure its metal contacts face

down.

3. Press

ON/OFF

4. Turn the wheel on the side of the Digital Book

System to adjust the screen contrast.

5. Press CARD .

6. Press or to highlight the HADI icon.

Installing the Digital Book

7. Press

ENTER

This is the main drug list, where you select drugs

to find interactions.

Installing the Digital Book

✓Resuming Where You Left Off

While using this digital book, you can turn off the

Digital Book System at any time. When you turn

the Digital Book System on again, the screen that

you last viewed appears. Any drugs entered in

your query list are saved, too.

✓Clearing the Main Drug List

You can always return to the main drug list by

pressing

CLEAR

. Note: When you do, the drugs

in your query list are also cleared.

You can return to the previous screen without

clearing your query list by pressing

BACK

Before you start using this digital book, you may

want to view a brief demonstration of its features and

functionality.

1. Press MENU at the main drug list.

2. Press to highlight

Demo

3. Press

ENTER

to start the demonstration.

4. Press

CLEAR

to stop the demonstration.

Viewing a Demonstration

✓ Help is Always at Hand

You can view a help message at any screen

(except during the demonstration) by pressing

HELP

. To read the help message, press .

To exit it, press

BACK

✓ Auto-shutoff

If you forget to turn this digital book off, don’t

worry. It will automatically shut off in four minutes.

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