Cytiva PH/C-902 Bedienungsanleitung

pH/C-902

Instruction

Important user information

All users must read the entire instructions to fully understand the

safe use of pH/C-902.

Safety notices

WARNING

WARNING indicates a hazardous situation

which, if not avoided, could result in death or

serious injury. It is important not to proceed until

all stated conditions are met and clearly

understood.

CAUTION

CAUTION indicates a hazardous situation which,

if not avoided, could result in minor or moderate

injury. It is important not to proceed until all

stated conditions are met and clearly

understood.

Note: A note is used to indicate information that is important for

trouble-free and optimal use of the product.

Declaration of conformity

This product meets the requirements of applicable CE-directives

when installed and used in an ÄKTAprocess™ system. A copy of the

corresponding Declaration of Conformity for the ÄKTAprocess

system is available on request.

The CE marking and the corresponding EU Declaration of Conformity

is valid for the instrument when it is:

•used according to the Operating Instructions or user manuals,

and

•used in the same state as it was delivered, except for alterations

described in the Operating Instructions or user manuals.

Introduction

The pH/C-902 Monitor is a high precision on-line monitor for

measurement of pH and conductivity in high performance liquid

chromatography applications.

The monitor is suitable for pH and conductivity measurements in

pharmaceutical applications where monitoring of running conditions

is critical.

The pH/C-902 Monitor is a combined monitor with two independent

measuring channels for both pH and conductivity.

The pH/C-902 features:

•Two separate pH measuring channels

•Two separate conductivity measuring channels

•Fast response

•High accuracy and reproducibility

•Flow cells with small dead volume

•Flow cells that can be connected close together, minimizing band

broadening and time delays between detectors.

•Control via UNICORN™ software only.

Safety

•The instrument is designed for indoor use only

•Do not use the instrument in a dusty environment or close to

spraying water

•Only use the instrument in accordance with local safety

regulations

WARNING

The instrument must not be opened by the user.

WARNING

Always disconnect the power supply before

attempting to replace any item on the

instrument during maintenance.

WARNING

The instrument power supply must be connected

to a grounded mains socket.

cytiva.com 14003958 AB

WARNING

When using hazardous chemicals, always use

protective glasses and other suitable personal

protection equipment.

Installation

The instrument is delivered pre-installed in ÄKTAprocess system

with all electrical connections prepared inside the electronics

cabinet. The conductivity cells and the pH electrode flow cell holder

are also mounted in proper positions.

WARNING

The electronics cabinet of the ÄKTAprocess

system must only be opened by personnel

authorized by Cytiva.

Operation

When the system is powered, the instrument is simultaneously

switched on. The monitor can be used immediately, but the full

specifications are not reached until after a warm-up period of

15 minutes.

The pH/C-902 Monitor has no user interface for the operator. It is

controlled entirely via UNICORN control software (version 5.0 or

later). The pH and conductivity values, as well as the temperature, are

displayed in the System Control module of the UNICORN control

software.

Note: The measured temperature is the temperature in the

conductivity flow cell, which can differ from the ambient

temperature.

Preparing the instrument

The following settings and calibrations may be necessary to perform

as described below:

•Set up conductivity temperature compensation

•Calibrate the conductivity cells

•Prepare and insert the pH electrode

•Calibrate the pH electrode

•Set up pH temperature compensation

Setting up the conductivity temperature compensation

The conductivity in a buffer is temperature dependent. Temperature

compensation should be used when relating conductivity to

concentration and/or comparing conductivity values. The

compensation consists of a compensation factor together with a

reference temperature. All conductivity values will then

automatically be converted to the set reference temperature.

In the UNICORN System Control module:

Step Action

1 Select System:Settings.

Result: The Instructions dialog box opens.

2 Select Monitors and click Cond_CIR101 or Cond_CIR102.

3 Enter a temperature compensation value between 0 and

9.99% in the CompFactor box.

4 Click OK.

The factor is expressed in percentage increase of conductivity per ℃

increase in temperature. If the temperature compensation factor is

unknown, a general approximate value of 2% can be set for many

common salt buffers.

Check the OFF-box in the Instructions dialog box for no

temperature compensation.

Calibrating the conductivity cell

Normally it is not necessary to adjust the cell constant as the flow cell

is pre-calibrated on delivery. The conductivity flow cell constant is

shown on the packaging and can be entered when the cell is

changed. Adjustment is only necessary when replacing the

conductivity cell with a flow cell whose constant is unknown.

However, it is also recommended that the flow cell is recalibrated

after cleaning.

The cell constant is adjusted in the UNICORN System Control

module.

Setting the constant for a new conductivity cell

The following instruction is applicable for a conductivity cell where

the constant value is known:

Step Action

1 Read the constant value from the packaging.

2 Selec System:Calibrate.

Result: The Calibration dialog box opens.

3 In the Monitor box, select CIT101_Cel or CIT102_Cel.

4 Type the constant value in the Reference Value 1 box.

5 Click the Read Value 1 button.

Result: The measured value is displayed in the Measured

value box.

6 Click the Close button to exit the dialog box.

Calibrating the conductivity cell

Note: The conductivity temperature compensation must not be

activated when the cell constant is adjusted. Set the

compensation to OFF in the Instructions dialog box.

Step Action

1 Prepare a calibration solution of 1.00 M NaCl, 58.44 g/l. Let the

solution rest until it is at room temperature. This is important

for exact measurements.

2 Fill the flow cell completely with the calibration solution by

pumping at least 15 ml through the cell with a syringe.

2 pH/C-902 Instruction 14003958 AB

Step Action

3 Stop the flow and wait 15 minutes until the temperature is

constant in the range of 20-30℃.

4 Read the displayed conductivity value and compare it to the

theoretical value at the temperature of the calibration solution

from the graph below.

No further actions are necessary if the displayed value and the

theoretical value correspond. If not, proceed with the following steps:

5 Select System:Calibrate.

Result: The Calibration dialog box opens.

6 In the Monitor box, select CIT101_Cal or CIT102_Cal.

7 Type the theoretical conductivity value according to the graph

below in the Reference Value 1 box.

8 Click the Read Value 1 button.

Result: The measured value is displayed in the Measured

value box. The new constant value is updated and displayed in

the Cell constant box.

9 Click the Close button to exit the dialog box.

Fig 1. Conductivity of 1.00 M NaCl at 20-30℃

Preparing and inserting the pH electrode

The tip of the pH electrode consists of a thin glass membrane.

protect it from breakage, contamination and drying out or the

electrode will be destroyed. Always store the electrode with the end

cover filled with a 1:1 mixture of pH 4 buffer and 1 MKO3. Do not store

in water only.

When it is not in use, e.g. during system CIP, service or storage of the

system, the pH electrode is replaced by a pH plug and the pH

electrode is placed in a holder that is attached to the frame adjacent

to the pH monitor

The instruction below describes how to insert the pH electrode:

Step Action

1 Unscrew the plastic fastening nut from the pH cell and remove

the pH plug.

2 Remove the pH electrode from its holder and take off the

protective cap. rinse the electrode with pure water.

Note:

The pH plug may be placed in the pH electrode holder while the

electrode is in use

3 Remove the fastening nut from the pH plug, insert the

electrode into the electrode adaptor and slide the nut over the

adaptor.

4 Carefully insert the electrode in the flow cell. Tighten the nut by

hand to secure the electrode.

5 Connect the monitor cable to the electrode.

6 Connect the grounding wire to the pH cell.

Fig 2. Inserting pH electrode into the flow cell

Note: if the electrode is not fully inserted, the system will leak and a

dead volume will occur in the holder.

CAUTION

Handle the pH electrode with care

Note: When running chromatography using organic solvents it is

recommended that the pH electrode is removed and the

dummy electrode is inserted in its place, as organic solvents

will cause pH electrode degeneration.

pH/C-902 Instruction 14003958 AB 3

Calibrating the pH electrode

A proper laboratory routine is to calibrate the instrument once a day,

when the electrode is replaced and if the ambient temperature is

changed. The pH monitor is calibrated using standard buffer

solutions in a two point calibration. The two buffer solutions can have

any pH value as long as the difference between them is at least 1 pH

unit.

The calibration can be performed with the pH electrode either fitted

in or removed from the flow cell.

Calibrating with the electrode outside the flow cell

When calibrating the electrode out of the flow cell and changing from

one buffer to another, rinse the electrode tip with distilled water and

dab it carefully with a soft tissue to absorb the remaining water. Do

NOT wipe the electrode as this may charge it and give unstable

readings.

Step Action

1 Remove the pH electrode from the flow cell and immerse the

electrode in the first standard buffer solution (normally pH 7.0).

2 Select System:Calibrate in the UNICORN System Control

module.

Result: The Calibration dialog box opens.

3 In the Monitor box, select pH_AIT121.

4 Enter the first reference pH value in the Reference value 1

box.

5 Click the Read Value 1 button.

Result: The measured value is displayed in the Measured

value box.

6 Rinse the electrode tip with distilled water and then immerse

the electrode in the second standard buffer solution (e.g. pH

4.0 or 9.0).

7 Enter the second reference pH value in the Reference value 2

box.

8 Click the Read Value 2 button.

Result: The measured value is displayed in the Measured

value box.

The Calibrated electrode slope box shows the slope of the

calibration curve where 100% corresponds to 59.16 mV per pH step at

25°C. The Asymmetry potential at pH 7 is shown as a mV value.

9 Before use, rinse the electrode using distilled water.

Calibrating with the electrode in the flow cell

Follow the same procedure as above. Ensure that the pH value has

stabilized before reading. Leave the pump running while calibrating.

Switch to the second standard buffer solution and repeat the

procedure.

Fig 3. Relationship between pH and the monitor output signal in mV

A new electrode typically has a slope of 95 – 102% and an asymmetry

potential within ±30 mV. As the electrode ages the slope decreases

and the asymmetry potential increases.

As a rule, an electrode should be replaced when it has an asymmetry

potential outside of ±60 mV and a slope lower than 80%, and no

improvement can be achieved by cleaning.

An electrode is still usable at lower slopes and higher asymmetry

potentials but the response will be slower and the accuracy

diminished.

Setting up pH temperature compensation

The relationship between pH and the output signal from the pH

electrode is temperature dependent. For more accurate

measurements during temperature changes, the pH measurement

can be temperature compensated. In normal applications, if the

temperature of the buffers and calibration buffers are identical,

temperature compensation does not need to be on.

When using temperature compensation it is important that the

temperature of the pH electrode is the same as that of the

conductivity flow cell since that is where the temperature is

measured.

The temperature compensation is activated in the UNICORN System

Control module:

Step Action

1 Select System:Settings.

Result: The Instructions dialog box opens.

2 Select Monitors.

3 Select pH_AIA121_TC.

4 Click the ON radio button.

5 Click OK to close the dialog box.

Storage

CAUTION

Never leave the pH electrode in the flow cell for

any period of time when the system is not used

since this may cause the glass membrane of the

electrode to dry out.

4 pH/C-902 Instruction 14003958 AB

Storage of the pH electrode

Step Action

1 Always dismount the pH electrode from the flow cell and fit the

end cover filled with a 1:1 mixture of pH 4 buffer and 1 M KNO3.

Do NOT store in water only.

2 Replace the pH electrode with the pH plug in the flow cell.

Regeneration of the pH electrode

If the electrode has dried out, immerse the lower end of the electrode

in buffer with a 1:1 mixture of pH 4 buffer and 1 M KNO3 overnight.

Storage of the conductivity flow cells

•Overnight: The conductivity cell can be left filled with a buffer.

•Weekend or long-term storage: Flush the conductivity cell

with water and fill the cell with 20% ethanol.

Restart after power failure

If the power supply to the instrument is interrupted, the instrument

automatically restarts itself when the power is resumed. All set

values are retained in the instrument.

Maintenance

WARNING

Disconnect the power supply before attempting

to replace any item on the instrument during

maintenance.

Only personnel authorized by Cytiva may service

the instrument.

CAUTION

Only spare parts approved or supplied by Cytiva

may be used for maintaining and servicing the

instrument.

Periodic maintenance

Interval Action

Every 6 months or more often if

required

Change pH electrode

When required Clean the conductivity cell

Clean the pH electrode

See procedures below

Cleaning the flow cell

Step Action

1 Remove the pH electrode and replace it with the pH plug in the

pH flow cell.

2 Pump a cleaning or sanitizing agent through the flow cells.

The standard recommendation is to pump 1 M NaOH for 30 minutes

and then wash out with buffer.

WARNING

NaOH is corrosive and therefore dangerous to

health. When using hazardous chemicals avoid

spillage and wear protective glasses and other

suitable personal protection equipment.

Cleaning the pH electrode

Note: The pH electrode has a limited life length and should be

replaced every six months or when the response time is slow.

Use one of the following procedures to clean the electrode to

improve the response:

Deposit Procedure

Salt Dissolve the deposit by immersing the

electrode first in 0.1 M HCl, then in

0.1 M NaOH, and again in 0.1 M HCl. Each

immersion should last for 5 minutes. Rinse

the electrode tip in distilled water between

each solution.

Oil or Grease Films Wash electrode tip in a liquid detergent and

water. If film is known to be soluble in a

particular organic solvent, wash with this

solvent. Rinse electrode tip in distilled water.

Protein Dissolve the deposit by immersing the

electrode in a 1% pepsin solution, in

0.1 M HCl, for 5 minutes, followed by a

thorough rinsing with distilled water.

If these procedure fail to rejuvenate the electrode, the problem is

most likely a clogged liquid junction.

Step Action

1 Heat a 1 M KNO3 solution to 60 – 80°C.

2 Place the electrode tip in the heated KNO3 solution.

3 Allow the electrode to cool while immersed in the KNO3

solution before retesting.

If these steps fail to improve the response of the electrode, it should

be replaced.

Changing the pH electrode

See Section Preparing and inserting the pH electrode, .

Cleaning the conductivity flow cell

If the conductivity measurements are not comparable to previous

results, the electrodes in the flow cell may be contaminated and

require cleaning. To clean the flow cell:

Step Action

1 Pump 15 ml of 1 M NaOH at 1 ml/min through the flow cell

either by using the pump or a syringe.

2 Leave it for 15 minutes.

3 Rinse thoroughly with 50 ml de-ionized water.

Note: If the flow cell is totally blocked, the blockage can be broken

using a thin needle or a piece of string with a diameter of less

than 0.8 mm.

pH/C-902 Instruction 14003958 AB 5

Changing conductivity flow cells

The flow cells can be changed when required. Make sure that the

system is disconnected from the mains power and de-pressurized

before disconnecting/ connecting the flow cells.

If the cell is replaced with a new flow cell, the monitor must be

calibrated with the new cell constant value which is written on the

flow cell package. See Section Calibrating the conductivity cell, .

Troubleshooting

General

When contacting Cytiva for support, access the UNICORN

Maintenance Manager in the System Control module to display the

instrument information, e.g. version number, for reference.

Step Action

1 Select System:Maintenance.

2 Select the Info tab.

3 Click the pH/Cond icon.

4 Click General.

WARNING

The electronics cabinet may only be opened by

Cytiva authorized personnel.

Faults and actions

If the suggested actions do not correct the fault, call Cytiva.

pH measurement

Fault Action

No response to pH

changes

1. Check that the electrode cable is

connected properly to the electrode.

2. The electrode glass membrane may be

cracked.

Replace the electrode.

Small response to pH

changes

1. Clean the pH electrode.

2. If the problem remains, replace the pH

electrode.

Slow pH response or

Calibration impossible

1. Check the pH electrode tip. If it is

contaminated, clean the electrode.

2. If the membrane has dried out, the

electrode may be restored by soaking it

in buffer overnight.

3. Clean the liquid junction.

Incorrect / unstable pH

reading

1. Check that the electrode cable is

connected properly to the electrode.

2. Check that the pump(s) and valves

operates correctly.

3. Check that the electrode is correctly

inserted in the flow cell and, if

necessary, hand-tighten the nut.

Fault Action

4. If air in the flow cell is suspected, tap

the flow cell or tilt it to remove the air.

Alternatively flush the flow cell with

buffer at 8 ml/min for 1/2 min.

5. Check that the pH electrode is not

broken.

6. Check that the pH electrode is

calibrated.

7. Check the slope. If it is outside the

range 80 – 105% or the asymmetry

potential deviates more than 60 mV

from 0mV, clean the pH electrode.

Recalibrate and if the problem

persists, replace the pH electrode.

8. Clean the pH electrode if required.

9. Compare the response of the pH

electrode with that of another pH

electrode. If the response differ

greatly, the electrode may require

cleaning or replacement.

10. Check that the pH electrode has been

calibrated at the correct temperature.

11. In organic solvents such as ethanol,

methanol and acetonitrile, stable pH

measurements are not possible since

dehydration of the membrane will

occur. It is recommended that the pH

electrode is not used in applications

using organic solvents. Replace the

electrode with the pH plug.

12. Clean the liquid junction.

pH values vary with

varying back-pressure

Replace the pH electrode.

Conductivity measurement

Fault Action

Incorrect or unstable

reading

1. Check that the conductivity flow cell

cable is connected properly.

2. Check that the pump(s) and valves

operate correctly.

3. If temperature compensation is being

used, check that the correct

temperature compensation factor is in

use.

4. Check that the column is equilibrated. If

necessary, clean the column.

Baseline drift or noisy

signal

1. There may be air in the flow cell. Use a

flow restrictor after the flow cell.

2. Check for leaking tubing connections.

3. Check that the column is equilibrated. If

necessary, clean the column.

4. Check the operation of the pump(s).

5. Clean the flow cell.

6 pH/C-902 Instruction 14003958 AB

Fault Action

Conductivity

measurement with the

same buffer appears to

decrease over time

1. Clean the flow cell.

2. The ambient temperature may have

decreased. Use a temperature

compensation factor. (See Section

Setting up the conductivity

temperature compensation, )

Absolute conductivity

value wrong

1. Recalibrate the conductivity cell.

2. The calibration solution, 1.00 M NaCl

was not correctly prepared. Prepare a

new calibration solution and

recalibrate the conductivity cell.

Ghost peaks appear in

the gradient profile

1. A charged sample has been detected

(e.g. protein)

2. Air bubbles are passing through the

flow cell. Check for loose tubing

connections. If necessary use a flow

restrictor after the conductivity flow

cell.

Error messages

If the suggested actions do not correct the fault, call Cytiva.

pH monitor

Error Help text message

pH not offset calibrated Must be factory calibrated, contact

service engineer.

Error in temp sensor If conductivity cell (where temperature

sensor is located) is not connected,

connect cell and restart system. If error

message reappears or conductivity cell is

already connected, contact service

engineer.

Warning: Bad slope Slope is < 70% or >100%. Clean the pH

electrode. If message reappears, replace

the pH electrode.

pH calibration failed Very bad slope, <10% or >199%. Check pH

cell connection. Recalibrate. If error

message reappears, replace the pH

electrode.

pH too close betw buff

1&2

The difference between pH of the buffers

used during calibration must be at least

1 pH unit.

pH-value is out of range pH must be in the range 0-14.

Bad or not conn pH

electr.

Defect pH electrode or pH electrode not

connected.

Error factory calibration

Factory calibration of negative offset

must be repeated, contact service

engineer

Conductivity monitor

Error Help text message

Cell const out of range 1. Wrong solution used during

calibration. Recalibrate.

2. Air in conductivity cell during

calibration. Flush the flow cell with

calibration solution and recalibrate.

Error Help text message

3. Dirty conductivity cell. Clean the cell.

Recalibrate.

4. Bad cell. Replace.

Error cond hardware Restart system. If error message

reappears, call service engineer.

Incorrect filter size Enter correct filter size.

Temperature monitor

Error Help text message

Error in temp sensor Temperature sensor in conductivity cell X

is broken or conductivity cell is not

connected. If conductivity cell is not

connected, connect cell and restart

system. If error message reappears or

conductivity cell is already connected,

contact service engineer.

Error temp comp Set correct temperature compensation

(0-9.95%) or if conductivity cell is not

connected, connect cell and restart

system. If error message reappears or

conductivity cell is already connected,

contact service engineer.

Error in temp sensor If conductivity cell (where temperature

sensor is located) is not connected,

connect cell and restart system. If error

message reappears or conductivity cell is

already connected, contact service

engineer.

Ref temp out of range Enter correct reference temperature

(0-99.9°C).

Reference information

pH electrode

The pH electrode is of the sealed combination double junction type. It

contains a sealed Ag/AgCl reference which cannot be refilled, an

internal electrolyte bridge of 4M KCl saturated with Ag/AgCl, an

outer electrolyte bridge of 1 M KNO3, an annular ceramic reference

junction and a low profile pH membrane. The pH electrode is

delivered with a transparent cover.

The flow cell should not be used with another pH electrode.

pH/C-902 Instruction 14003958 AB 7

Fig 4. pH electrode cross-section

Conductivity cell

The flow cell has two cylindrical titanium electrodes positioned in the

flow path of the cell. An alternating voltage is applied between the

electrodes and the resulting current is measured and used to

calculate the conductivity of the eluent. The monitor controls the AC

frequency and increases it with increasing conductivity between

50 Hz and 50 kHz giving maximum linearity and true conductivity

values.

The conductivity is automatically calculated by multiplying the

measured conductance by the flow cell’s cell constant. The cell

constant is pre-calibrated on delivery but can be measured with a

separate calibration procedure. This procedure is described in

Section Calibrating the conductivity cell, .

One of the electrodes has a small temperature sensor for measuring

the temperature of the eluent in the flow cell. Temperature variations

influence the conductivity and in some applications, when highly

precise conductivity values are required, it is possible to program a

temperature compensation factor that recalculates the conductivity

to a set reference temperature.

Fig 5. Conductivity cell – principle

Technical specifications

Operating data

General

Operating temperature

for monitor

4 – 40°C

Operating surrounding

temperature for cells

2 – 30°C

Surrounding humidity 20 – 95% rH

pH measurement

pH range 0 to 14 (spec. valid between 2 and 12)

Accuracy

temperature

compensated1

±0.1 pH within +4 to +40°C

not temperature

compensated1

±0.2 pH within +15 to +25°C

±0.5 pH within +4 to +40°C

Response time Max 150 s (0-95% of step)

Long term drift Max 0.1 pH units/8 h

(constant conditions)

Flow rate sensitivity Max 0.2 pH units within 50l/h - 200 l/h

20°C

1Calibrated for 20°C

Conductivity measurement

Conductivity range 1 μS/cm - 999.9 mS/cm

Deviation from true

conductivity value

Max ± 4 % or ±10 μS/cm, whichever is

greater, in the range 1 μS/cm –

300 mS/cm

Max ± 2 % or ±10 μS/cm, whichever is

greater, in the range 0,1 μS/cm –

100 mS/cm (at room temperature)

Reproducibility

short term Max ±1 % or ±5 μS/cm

long term Max ±3 % or ±15 μS/cm

Noise ±0.5% of full scale calibrated range

Response time Max. 120 s (0 – 95% of step)

Temperature sensor

Accuracy ±2.0°C

Drift ±1%/10 h

Flow rate sensitivity ±1% within 50 l/h – 200 l/h 20°C

Flow cell data

pH cell

Cell sizes:

6 mm For use in:

6mm Polypropylene systems

3/8” Stainless steel systems

10 mm For use in:

10mm Polypropylene systems

1/2” Stainless steel systems

22 mm For use in:

1” systems (PP and SS)

8 pH/C-902 Instruction 14003958 AB

pH cell

Flow range 4 – 180 l/h (6 mm cell)

13 – 600 l/h (10 mm cell)

45 – 1800 l/h (22 mm cell)

Max pressure 10 bar (6 and 10 mm cell)

6 bar (22 mm cell)

3 bar up to +60°C (all cells)

1 bar up to +80°C (all cells)

Back pressure Max 0.1 bar at 600 l/h (6 and 10 mm cell)

Max 0.1 bar at 1800 l/h (22 mm cell)

Wetted materials PEEK and Polypropylene (polypropylene

systems)

PEEK and EN 1.4435 (stainless steel

systems)

Sealing: EPDM, FEP encapsulated silicone

Chemical resistance The wetted parts are resistant to organic

solvents and salt buffers commonly used

in chromatography of biomolecules,

except 100% Ethyl acetate, 100% Hexane

and 100% Tetrahydrofuran (THF)

Conductivity cell

Cell sizes:

8 mm For use in:

6 and 10 mm Polypropylene systems

3/8” and 1/2” Stainless steel systems

12 mm For use in:

1” Polypropylene systems

1” Stainless steel systems

Flow range 4 – 600 l/h (8 mm cell)

45 – 1800 l/h (12 mm cell)

Max pressure 10 bar (8 mm cell)

6 bar (12 mm cell)

3 bar up to +60°C (all cells)

1 bar up to +80°C (all cells)

Back pressure Max 0.1 bar at 600 l/h (8 mm cell)

Conductivity cell

Max 0.2 bar at 1800 l/h (12 mm cell)

Wetted materials PEEK, Polypropylene and Titanium

Sealing: EPDM, FEP encapsulated silicone

Chemical resistance The wetted parts are resistant to organic

solvents and salt buffers commonly used

in chromatography of biomolecules,

except 100% Ethyl acetate, 100% Hexane

and 100% Tetrahydrofuran (THF)

Accessories and spare parts

Item Quant Code no.

Transmitter pH/C-902 1 28-4019-33

pH electrode CPS11-1BA2ESA 1 44-5514-99

pH Cable CPK9 TOP68 L=5 1 44-5514-85

O-ring kit pH PFR91 1 44-3004-70

pH flowcell PEEK/PFR91 Process

connection: 3/4” Tri-Clamp (TC25), ID

9.4mm

1 28-4022-28

Conductivity sensor 8mm EPDM 1 28-4021-98

Conductivity sensor 8mm FEP 1 28-4021-99

O-ring kit CM-C EPDM

2pcs O-ring 25.07x2.62 EPDM

6pcs O-ring 10.78x2.62 EPDM

1pc O-ring 58x3.0 EPDM

1pc Assembly rod

1 28-4022-00

O-ring kit CM-C FEP

2pcs O-ring 25.07x2.62 EPDM

6pcs O-ring 10.77x2.62 FEP

1pc O-ring 58x3.0 EPDM

1pc Assembly rod

1 28-4022-01

cytiva.com/bioprocess

Cytiva and the Drop logo are trademarks of Global Life Sciences IP Holdco LLC or an

affiliate.

ÄKTAprocess and UNICORN are trademarks of Global Life Sciences Solutions USA

LLC or an affiliate doing business as Cytiva.

All other third-party trademarks are the property of their respective owners.

All goods and services are sold subject to the terms and conditions of sale of the

supplying company operating within the Cytiva business. A copy of those terms and

conditions is available on request. Contact your local Cytiva representative for the

most current information.

For local office contact information, visit cytiva.com/contact

14003958 AB V:5 05/2021

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