Integra DOSE IT Bedienungsanleitung

DOSE IT Operating instructions

171250_V08

Declaration of conformity

INTEGRA Biosciences AG –

7205 Zizers, Switzerland

declares on its own responsibility that the device

complies with:

Zizers, November 4, 2016

Description Model

DOSE IT P910 171 000

EU Directives (DoW: Date of Withdrawal) Before DoW DoW After DoW

Low Voltage Equipment 2006/95/EC 20.04.2016 2014/35/EU

Electromagnetic Compatibility 2004/108/EC 20.04.2016 2014/30/EU

Restriction of Hazardous Substances 2011/65/EU

Waste Electrical and Electronic Equipment 2012/19/EU

EU Regulations

Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH)

1907/2006

Ecodesign - Power supplies 278/2009

Standards for EU

Safety requirements for electrical equipment for measurement, 

control and laboratory use - General requirements.

EN 61010-1: 2010

Electrical equipment for measurement, control and laboratory use -

EMC requirements.

EN 61326-1: 2013

Standards for Canada and USA

Safety requirements for electrical equipment for measurement, 

control and laboratory use - General requirements.

CAN/CSA-C22.2

No. 61010-1

Safety requirements for electrical equipment for measurement, 

control and laboratory use - General requirements.

UL 61010-1

Operation is subject to the following two conditions: 

(1) this device may not cause harmful interference, and 

(2) this device must accept any interference received, including

interference that may cause undesired operation.

Part 15 of the

FCC Rules

Class A

Elmar Morscher

CEO

Thomas Neher

Quality Manager

DOSE IT – Operating instructions V08

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Table of contents

Chapter 1 Introduction

1.1 Intended use ..................................................................................5

1.2 Symbols used.................................................................................5

1.3 Safety notes ...................................................................................6

Chapter 2 Description of the device

2.1 Scope of delivery............................................................................7

2.2 Overview of the DOSE IT...............................................................7

Chapter 3 Installation

3.1 Power supply connection ...............................................................9

3.2 Retort rod and filling arm (optional)................................................9

Chapter 4 Operation

4.1 Selection and loading of the tubing ..............................................10

4.2 Parameter settings .......................................................................13

4.3 Adjusting the dispensing program................................................15

4.4 Calibrating the pump ....................................................................18

4.5 Performing the dispensing process..............................................19

4.6 Working in Pump mode................................................................19

4.7 Using the double pumphead configuration (optional)...................20

4.8 Process documentation (optional)................................................21

4.9 Using the foot and benchtop switch .............................................22

4.10 Remote control by a PC .............................................................22

Chapter 5 Maintenance

5.1 Cleaning and servicing.................................................................23

5.2 Decontamination ..........................................................................23

5.3 Leak Test .....................................................................................23

5.4 Disposal .......................................................................................24

Chapter 6 Technical data

6.1 Environmental conditions .............................................................25

6.2 Specifications ...............................................................................25

6.3 Current consumption depending on input voltage........................25

6.4 Chemical compatibility .................................................................26

DOSE IT – Operating instructions V08

4 INTEGRA Biosciences AG

Chapter 7 Accessories and consumables

7.1 Consumables ...............................................................................27

7.2 Spare part ....................................................................................28

7.3 Accessories..................................................................................29

Imprint .................................................................................................30

DOSE IT – Operating instructions V08 Introduction

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1 Introduction

1.1 Intended use

This is a general-purpose laboratory instrument. Any use of this instrument in a medical

or IVD setting is the sole responsibility of the user.

The programmable peristaltic pump DOSE IT is designed for pumping and dispensing

liquids in a volume range of 0.1 ml to 9999 ml using silicone tubings.

If the DOSE IT is used in a manner not specified by INTEGRA, the protection provided by

the DOSE IT may be impaired.

1.2 Symbols used

This operating instruction manual makes specific reference to residual dangers using the

symbols shown below.

1.2.1 Hazard warnings in these operating instructions

WARNING

This safety symbol advises of hazards that could result in injury or death.

It also indicates hazards for machinery, materials, and the environment.

It is essential that you follow the relevant precautions.

CAUTION

This symbol cautions about potential material damage or data loss in a

microprocessor controller. Follow the instructions.

NOTE

This symbol identifies important notes regarding the correct operation of the

device and labor-saving features.

1.2.2 Hazard warnings on the device

ROTATING COG WHEELS

Risk to squash your fingers.

DOSE IT – Operating instructions V08 Introduction

6 INTEGRA Biosciences AG

1.3 Safety notes

The DOSE IT conforms to the state of technology and the recognized safety rules, and is

operationally safe. Operate the DOSE IT when in perfect conditions only and observing

this user manual.

Residual dangers can emanate from the device if it is used or operated incorrectly by

untrained personnel. All persons entrusted with operation of the DOSE IT must have read

and understood this user manual and, in particular, the safety notes, or must have been

instructed by their superior such that they are able to operate the device without danger.

Please observe the danger references on the device.

Do not carry out any conversion work or alterations on the device.

Irrespective of the safety instructions set out here, applicable provisions and regulations

must be observed in addition; for example, GLP, GMP, FDA, of the employer's liability

insurance associations, of the health authorities and of the trading standards authorities.

Please visit our website www.integra-biosciences.com on a regular basis for up to date

information regarding REACH classified chemicals contained in our products.

DOSE IT – Operating instructions V08 Description of the device

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2 Description of the device

2.1 Scope of delivery

• DOSE IT P910 peristaltic pump

• Silicone tubing, autoclavable, 4 mm inner diameter (ID)

• 2x Aspiration/dispensing tubes 10 cm, stainless steel, 4 mm ID, 

one end dented

• Aspiration tube 35 cm, stainless steel, 4 mm ID, one end dented

• Tube collar

• AC adapter

• Operating Instructions

2.2 Overview of the DOSE IT

Front view

1Housing

2 Operating panel with display and keypad

3 Pumphead

Operating panel

4 Back-key

5 Function keys

6 Arrow keys

456

DOSE IT – Operating instructions V08 Description of the device

8 INTEGRA Biosciences AG

Rear view

7 Screw threads for fixation of the retort rod

8 Handhold

9 Connections and mains switch (see below)

78 9

Connections and mains switch

10 RS-232 interface for connection with serial printer

11 RS-232 interface for service connection

12 AUX connection for controlling a second DOSE IT

13 Mains switch

14 Connection for foot switch, benchtop switch,

MEDIAJET or external relay contact (potential free,

normally open, 3.5 mm jack plug) for remote control

15 Mains connection socket

DOSE IT – Operating instructions V08 Installation

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3 Installation

The DOSE IT is a ready-to-use peristaltic pump that requires only a minimal installation

procedure. It shall be installed on a planar surface, in a dry and dust-free environment.

NOTE

Before proceeding with the installation compare the contents of the package

with the list “2.1 Scope of delivery” on page 7. Should something be missing

or should you find a faulty component, please contact your local INTEGRA

Biosciences representative.

3.1 Power supply connection

Connect the AC adapter cable to the DOSE IT mains connection socket and plug it to the

electricity mains.

WARNING

The supply voltage must meet the requirements of the AC adapter:



100-240 VAC, 50-60 Hz.

3.2 Retort rod and filling arm (optional)

Fix the retort rod with the two screws on the rear side, using

a Phillips screwdriver (PH2), see "Screw threads for fixation

of the retort rod" on page 8.

Mount the filling arm onto the rod and tighten it with the side

lever in order to prevent it from moving during dispensing.

DOSE IT – Operating instructions V08 Operation

10 INTEGRA Biosciences AG

4 Operation

The DOSE IT operates in different modes: DISPENSE mode for distribution of a defined

volume into containers and PUMP mode for continuous pumping of liquids. In addition,

customized applications can be defined (software version 2.0 and higher).

4.1 Selection and loading of the tubing

4.1.1 Tubing selection

The pumphead of the DOSE IT is compatible with differently sized tubing allowing the user

to dispense a wide range of dose volumes. The main criteria for the choice of tubing are

the speed and precision requirements of a specific application. The larger the inner

diameter (ID) of the tubing, the faster but less precise is the dispensing.

As a reference for selecting the appropriate inner diameter of the tubing, typical volume

and speed values for different tubing sizes are listed in Table 1.

NOTE

The indicated volume values relate to the specified reproducibility and not to

the actual limits of the system. The values have been determined

experimentally and may vary slightly depending on the experimental set up.

Compatibility with the pumphead and specified reproducibility can be guaranteed for

original INTEGRA Biosciences’ tubing only.

NOTE

8 mm ID tubing is only recommended for the “PUMP” program mode (for

accuracy reasons, drips between the aliquots and draw backs in the tubing

may be a problem).

Table 1: Typical volume and speed values

Tubing inner diameter (ID) 1 mm 2 mm 3 mm 4 mm 6 mm

Volume (ml) at CV* < 1 % > 0.5 > 1 > 3 > 7 > 15

Speed range (ml / min) 0.6 – 52 2.1 – 203 4.8 – 475 8.4 – 837 16 – 1634

* Coefficient of variation.

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