Millipore Labscale Bedienungsanleitung
Labscale™Tangential
Flow Filtration System
User Guide
2 www.millipore.com
Notice
The information in this document is subject to change without notice and should
not be construed as a commitment by Millipore Corporation. Millipore Corporation
assumes no responsibility for any errors that may appear in this document. This manual
is believed to be complete and accurate at the time of publication. In no event shall
Millipore Corporation be liable for incidental or consequential damages in connection
with or arising from the use of this manual.
Labscale Tangential Flow Filtration System User Guide 3
Contents
Introduction 5
Operator and Equipment Safety 5
Labscale Stirbase Setup 6
Module set up 6
Operating Requirements 7
System Overview/Unpacking Lists 8
Labscale TFF System 8
Labscale 500 mL Reservoir 9
Labscale Stir Base 11
Labscale Pump Module 12
Pellicon XL 50 Device 13
User Supplied Materials 13
Labscale TFF System Setup 14
Labscale 500 mL Reservoir Setup 16
Labscale Stir Base Set Up 19
Labscale Pump Module Set Up 21
Install Cleaning Tubing 25
Install Cleaning Tubing 25
Clean System 26
Drain System 27
Flush System 29
Flushing Device 30
Install Pellicon XL Device 30
Flushing 31
Drain System 33
Integrity Testing—Pellicon XL Device on System 33
Preconditioning 34
Concentration 35
Product Recovery 37
Dialtration—Vacuum 38
Shutdown 40
Cleaning Device 40
Clean System 40
Drain System 42
Flushing Device 42
Clean Base 42
Specications 43
Specications 43
Materials of Construction 43
ECComplianceCerticate 44
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Labscale TFF SystemOrdering Information 45
Labscale TFF system kit 45
Compatible pumps and pump head 46
Pellicon XL Devices 46
Labscale TFF System Maintenance 47
Labscale Stir Base Spare Parts 47
Labscale 500 mL Reservoir Spare Parts 47
Labscale Pump Module Spare Parts 49
PumpCheckValveFlushing 50
Diaphragm Pump Maintenance 51
Electrical Schematic 53
Labscale TFF SystemTroubleshooting 54
Electrical/Control 54
Performance 55
Pressure 56
Technical Assistance 58
Labscale Tangential Flow Filtration System User Guide 5
Introduction
The Labscale TFF system is a simple, easy to use system, designed
specifically for the Pellicon®XL device. This modular system
includes a 500 mL acrylic reservoir with pressure gauges, device
docking manifold and retentate valve; system base with integral
magnetic stirrer and diaphragm pump. The design of this system
allows Millipore’s Pellicon XL device to dock directly onto the side
of the reservoir, making tubing connections short, minimizing
holdup and recirculation volumes.
Operator and Equipment Safety
Anyone operating or working near the Labscale system must be
aware of the following:
• Read and understand this Operators Manual before performing
maintenance on the system. Failure to follow instructions could
result in user injury or system damage.
• Read and understand all maintenance instructions in this operating
instruction manual before performing maintenance on the system. Failure
to follow instructions could result in user injury or system damage.
• Prior to operation, ensure the Labscale system is fully assembled
as described in Labscale TFF System Setup. Ensure all pumps and
sensors are properly conected to their connection ports on the system.
• Never operate the Labscale system in a hazardous environment or
use with flammable, combustible or solvent liquids.
• Any alteration of the Labscale system from factory specification
may cause unsafe conditions and will void the product warranty.
• Use appropriate power supply cable and fuses for the area where
the Labscale system is operated for information, see Labscale
Stirbase Setup.
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Labscale Stirbase Setup
• If you order the pump module separatly, ensure pump module
wiring connections are correctly installed, see Chapter “Labscale
Pump Module set up”.
Module set up
Risk of electric shocks
• Unplug power cord prior to opening the blank panel from system base.
• There are no user-serviceable parts inside the Labscale system.
• Service should be performed only by trained and authorized
personnel.
Risk of rupture
• Use caution when opening and closing valves. Failure to open or
close valves at the appropriate times could result in trapped high
pressure, product loss, damaged cassettes, chemical spills, and
pump damage. Carefully follow all operating instructions
• Prior to each use, carefully inspect all hoses and tubing for kinks
or restrictions that could result in pressure buildup and possible
rupture of hoses or tubing.
• Prior to each use, carefully check that tubing at pump outlet to feed
in port (FEED IN) and cleaning tubing are Sta-Pure (white) tubing.
Failure in correctly installing Sta-Pure (white) tubing can result in
overpressurized tubing and burst.
• Transfer pump tubing can rupture due to continuous contact
with moving parts. Follow tubing manufacturer’s recommended
replacement interval.
• Never move the system while there is liquid in the tank, while
system processes are running or the cassettes is in place.
Labscale Tangential Flow Filtration System User Guide 7
• Never operate the system without the tank cover in place. Never
operate the system if any moving parts are exposed. Never operate
the system with the pump housing open.
• Use appropriate personal protective equipment, including eye
protection, when operating the system.
This equipment can potentially be used with biohazardous
products.
Operating Requirements
The system needs to be connected to electrical power and have
fuses installed to operate.
The Labscale system must only be uesd with the Millipore wall
transfomer provided and Millipore accessories.
Location Power Supply Reference
North America
Japan
115 VAC 50/60Hz, 1-phase XX42LSS11
Europe,
China
230 VAC 50/60Hz, 1-phase XX42LSS12
United Kingdom 230 VAC 50/60Hz, 1-phase XX42LSS13
Operating Conditions
The maximum operating altitude 2000 m
The over voltage category 2
The temperature operating range 40 to 25 °C (39 to 77 °F)
in a non-condensing
environment
Storage Conditions
The temperature storage range -10 C to 55 °C (14 to 131
°F) in a non-condensing
environment
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System Overview/Unpacking Lists
Labscale TFF System
The Labscale TFF System is shipped in an overpack carton that
contains three separate cartons. One carton contains the Labscale
500 mL Reservoir, one contains the Labscale Stir Base with the
Labscale pump module installed, one contains the AC Adapter.
Figure 1: The Labscale TFF System, Catalog No. XX42LSS11(115V),
XX42LSS12(230V), XXL425513(230V GB).
Labscale Tangential Flow Filtration System User Guide 9
Labscale 500 mL Reservoir
The reservoir manifold and instruments are an integrated system.
The feed pressure gauge indicates the pressure of the fluid being
pumped into the Pellicon XL device. The retentate pressure gauge
indicates the pressure of the fluid exiting the Pellicon XL device.
The upper manifold includes a retentate back pressure valve. The
fittings used are polypropylene and stainless steel.
1 shut-o
valve
10 ttings
10 ttings
10 clamps
1 syringe
1 Millex
Vent
1 Operating
Manual
1 stir bar
Retentate Pressure Gauge
Retentate Back
Pressure Valve
Feed Pressure Gauge
3 Rotating
Lock Rings
6 feet (1.8m) of Silicone
(translucent) tubing
1/8" (3mm) ID
Figure 2: Labscale 500 mL Reservoir, Catalog No. XX42RES01
10 www.millipore.com
The following items are also packed with your Labscale 500 mL
Reservoir:
1 Shut-o Valve
10 Fittings
10 Fittings 10 Clamps
1 Syringe
1 Stir Bar
1 Millex
®
Vent
1 Operating Manual
3 Rotating
Lock Rings
6 feet (1.8 m) of Silicone
(translucent) tubing
1/8 in. (3 mm) ID
2 x 1 ft (0.3m) of Sta-Pure®
peristaltic pump tubing
1/8 in. (3 mm) ID.
Figure 3: Labscale 500 mL Reservoir Accessories
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