Pari EFlow rapid Bedienungsanleitung

Cap and seal

Control unit

Power button

Connection cord socket

Medication reservoir

Aerosol head

Aerosol chamber

Inspiratory valve

Mouthpiece

Preassembled

nebuliser parts*

A quick reference guide. For full details, please read and take note of the Instructions For Use.

Assembly and inhalation

Assemble Hold the nebuliser horizontally to inhale

PARI GmbH – Spezialisten für effektive Inhalation, Moosstraße 3, D-82319 Starnberg, Tel: 0049 (0) 8151 / 279 - 220

With mouthpiece

With mask (for ages 2 and older)

A note about the medication reservoir:

A small amount of medication that must not be used

is left in the reservoir. It must be disposed of. Similar

quantities of medication also remain unused in the

PARI LC PLUS®nozzle nebuliser.

* The aerosol chamber and the medication reservoir are preassembled

and cannot be taken apart.

PARI SMARTMASK®Kids (Part no. 078G5000)

eFlow rapid Arzneimittelkarte für Ärzte EN 20.09.2006 14:05 Uhr Seite 1

Practitioner´s information: Inhalation therapy with eFlow®rapid:

Inhalation Solutions & Treatment Time

Active Agent

Concentration1)

Substance

Class1)

eFlow® rapid

Details

TOR

g/min 4)

MMD

μm 4)

RF %

< 5μm 4)

Time

Min

Tobramycin

300mg/5 ml

Aminoglycoside

Antibiotic

Serum level is comparable to standard therapy using

the PARI LC PLUS® nebuliser. Serum value approx.

1 μg/ml data on file (n=9).2)

Tested with TOBI®(Chiron/Novartis) 0.50 3.9 73 6-8

Colistimethate sodium

79 mg (1 Mio units)/3 ml

Polymyxine

Polypeptide Antibiotic

Colistin powder has to be dissolved carefully in 3 ml

0.9 % sodium chloride solution.

Tested with Colistin CF (Grünenthal) 0.58 3.9 69 3-4

Salbutamol

2.5 mg/2.5 ml

Bronchodilator

Beta 2 mimetic

Comparable treatment safety: Heart rate pre and post

delivery of Salbutamol (10 min after inhalation) is

comparable to LC PLUS® nebuliser. Data on file (n=10).2)

Tested with Sultanol®forte (Glaxo Smith Kline)

0.68 4.3 64 2-3

Ipratropiumbromide

500 μg/2 ml

Bronchodilator

Anticholinergic

Tested with Atrovent®(Boehringer Ingelheim) 0.69 4.3 63 1-2

Dornase alfa

2.5 mg/2.5 ml

Mucolytic agent Enzymatic activity remains largely stable

after nebulization (90%) as for PARI LC PLUS®

nebuliser 2)3). Tested with Pulmozyme®(Roche) 0.61 3.9 72 2-3

Acetylcysteine

300 mg/3 ml

Mucolytic Tested with Fluimucil®(Zambon) 0.60 4.1 70 4-5

Medical product:

Isotonic sodium chloride

solution (0.9 %) 2.5 ml

PARI NaCl Inhalation Solution

Secretolytic Individual treatment schedule.

Tested with PARI NaCl Inhalation Solution

0.70 4.3 67 2-3

Dispensed hypertonic

saline solution

(Sodium chloride 5.8%) 2.5 ml

Secretolytic Individual treatment schedule.

Tested with dispensed saline solution 5.8 % 0.69 4.2 69 2-3

1) These agents are approved for inhalation therapy in Germany. 2) Seemann et al: Improving aerosol drug delivery in CF therapy. European Cystic Fibrosis Society, 28 th European Cystic Fibrosis

Conference, Crete, Greece, June 22-25, 2005. 3) Lichtinghagen (2004 and 2005), MHH. 4) PARI internal tests, measured with the

Malvern MasterSizer X at 23°C and 50% relative humidity. Inspiratory flow 20 l/min. TOR, MMD, RF, time (mean values).

eFlow rapid Arzneimittelkarte für Ärzte EN 20.09.2006 14:05 Uhr Seite 2

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