Sartorius BioPAT Xgas Bedienungsanleitung

Operating Instructions | Betriebsanleitung

BioPAT

®Xgas

85032-544-12

English page 3

Deutsch Seite 42

The enclosed CD contains the operating instructions

as a PDF file in various international languages.

If the CD is missing, you can obtain a copy form us

by specifying the order number:

Order number: 85037-548-53

System Requirements:

Windows, MacOS X

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PDF-Reader

Use start.html to run the application

Contents

Operating Instructions BioPAT

®Xgas 3

Contents

1 Introduction .............................................................5

1.1 Function ..............................................................5

1.2 Target Group..........................................................5

1.3 Notes on Using these Instructions ....................................5

2 Safety Instructions .......................................................7

2.1 General Information ..................................................7

2.2 Authorized Personnel.................................................7

2.3 Intended Usage .......................................................7

2.4 Limitations of Use and Misuse ........................................8

2.5 Process-related Hazards ..............................................9

3 Design and Function ....................................................10

3.1 Measurement Principles .............................................10

3.1.1 Pressure Measurement .......................................12

3.1.2 Humidity Measurement ......................................12

 ............................................12

  .............................................12

4 Installation ..............................................................13

4.1 Equipment ...........................................................13

4.1.1 Unboxing and assembling ....................................14

4.2 Setup.................................................................17

4.3 Assembly.............................................................17

4.4 Connection ..........................................................18

4.5 Arrangement on the Bioreactor and Assembly.......................24

Contents

4 Operating Instructions BioPAT

®Xgas

5 Operating Information..................................................25

5.1 Safety Instructions .................................................. 25

5.2 In-process Exhaust Air Analysis ..................................... 26

5.2.1 Switching on the BioPAT®Xgas .............................. 26

5.2.2 In-process Measurement .................................... 28

5.2.3 Sensor Status Display via LEDs ..............................30

5.3 Troubleshooting......................................................31

5.3.1 Faults or Malfunctions from Moisture in the Exhaust Air .....31

5.3.2 Leaktightness Test............................................32

6 Maintenance and Service ...............................................33

6.1 Maintenance by the Customer.......................................33

6.1.1 Calibration....................................................33

6.1.2 Filter Replacement .......................................... 34

7 Appendix................................................................36

7.1 Calibration Table . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 36

8 Technical Data ..........................................................37

9 Disposal................................................................40

9.1 Information on Decontamination ...................................40

9.2 Dispose of Device and Parts ........................................40

9.2.1 Information on Disposal .....................................40

9.2.2 Disposal......................................................40

10 Conformity Documents .................................................41

Operating Instructions BioPAT

®Xgas 5

Introduction

1 Introduction

1.1 Function

These operating instructions describe the safe installation and use of the

BioPAT®Xgas.The operating personnel must read these instructions prior to

operational startup. These instructions should always be available at the

workplace.

1.2 Target Group

These operating instructions are designed for qualified personnel. Only

qualified personnel may set up BioPAT®Xgas, connect it to the bioreactor or

perform in-process operation or maintenance.

1.3 Notes on Using these Instructions

All information in these operating instructions considers the state of the art,

the applicable standards and guidelines, and our many years of experience

and knowledge.

These operating instructions provide you with all the information necessary to

install and operate the BioPAT®Xgas (referred to as “device” in the following).

The operating instructions must be read and used by all persons entrusted

with the operation, service, cleaning, and troubleshooting of the device.

This applies particularly to the safety instructions listed.

t Please read these operating instructions carefully and completely before

using this device.

t These instructions are part of the product. Keep them in a safe and easily

accessible place near the device’s site of installation.

t If the instructions should be lost or misplaced, please contact Sartorius

Stedim Biotech for a replacement or download the latest version from our

website: www.sartorius.com

6 Operating Instructions BioPAT

®Xgas

Introduction

Symbols Used

As a means of instruction and direct warning

against hazards, all text statements to be particu-

larly noted in these operating instructions will be

marked as follows:

This symbol denotes a possible danger with risk

that moderate or minor injury may result if it is

not avoided.

This symbol denotes a danger with low risk that

could result in property damage if it is not avoided.

This symbol indicates useful information or a

function|setting on the device, or that caution

should be exercised while working.

The following presentations will also be used:

Texts that follow this mark are lists.

t Texts that follow this mark describe

activities that must be carried out in

the specified order.

y Texts that follow this mark describe

the result of an action.

“ ” Texts in quotes are references to other

chapters or sections.

CAUTION

IMPORTANT

Operating Instructions BioPAT

®Xgas 7

Safety Instructions

2 Safety Instructions

2.1 General Information

Sartorius Stedim Biotech supplies the BioPAT®Xgas after careful testing in

ready-for-operation condition.

This manual contains instructions for the safe operation of the BioPAT®Xgas.

You may only operate the device under conditions that comply with the

specifications stated in this manual and the information on the manufacturer’s

ID label.

2.2 Authorized Personnel

The following persons may carry out the actions described here:

Operations Persons

Assembly and connection at|to

the bioreactor; function test, basic

calibration during servicing and

maintenance

Trained and qualified personnel of

the operator or service technicians

of Sartorius Stedim Biotech

Operation, in-process 1-point

calibration

Personnel who has read this

documentation and is familiar with

the operation of bioreactors

Factory maintenance and service Sartorius Service

2.3 Intended Usage

The BioPAT®Xgas is a gas sensor for measuring carbon dioxide and oxygen

contents in the defined concentration range and under the conditions



during biological processes such as fermentations.

8 Operating Instructions BioPAT

®Xgas

Safety Instructions

2.4 Limitations of Use and

Misuse

Danger of malfunctions and damage to the

sensor under impermissible measuring

conditions!

The BioPAT®Xgas is not designed according to

the ATEX Directive.

t Do not use the sensor

in flammable or explosive atmospheres or

with such gases!

in gases with polymers or silicone

components

in gases with halogens like F, Cl, Br etc.,

CFC

in gases with SOx and H2S.

t Prevent water or humidity (RH <75%) from

entering into the sensor when the sensor is

switched on.

t Dry the sensor when humidity condenses in

the exhaust line and condensate has entered

into the sensor.

The BioPAT®Xgas is unsuitable for use as safety

equipment for system gas monitoring or as a gas

warning device. This constitutes misuse.

IMPORTANT

Operating Instructions BioPAT

®Xgas 9

Safety Instructions

2.5 Process-related Hazards

Risk of poisoning for persons when CO2is

released into the room! Risk of inflammation

for flammable materials if gases enriched with

oxygen escape into the room air!

t Determine the max. concentrations of gas

released into the room and evaluate whether

they could lead to hazardous situations, e.g. if

the room ventilation fails.

t Ensure that your work area is well ventilated

or connect the BioPAT®Xgas to the available

exhaust air fittings in your laboratory.

t Check all connections for leaks.

CAUTION

10 Operating Instructions BioPAT

®Xgas

3 Design and Function

The BioPAT®Xgas combines one oxygen and one carbon dioxide sensor

featuring automatic compensation of humidity and pressure into one



adapter past the measuring chambers. During this process, the pressure,

humidity, oxygen and carbon dioxide concentration are measured.

The sensors measure the gases in the concentration ranges and under the





e.g. the DCU systems of bioreactors Biostat®C Plus, B and B-DCU II.

The measurement and control system shows measurements on the display,



measurement and control system.

3.1 Measurement Principles

The analyzer features 4 different measuring components:

1. Pressure measurement

2. Humidity measurement

3. CO2measurement

4. O2measurement

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