Agilent Technologies 1260 Infinity II Bedienungsanleitung

Agilent 1260 Infinity II

Multi-Angle Light Scattering Detector

User Manual

Notices

Manual Part Number

Document No: D0029607 Rev. B

Edition 07/2023

No part of this manual may be

reproduced in any form or by any

means (including electronic storage

and retrieval or translation into a

foreign language) without prior

agreement and written consent from

Agilent Technologies, Inc. as governed

by United States and international

Agilent Technologies

Hewlett-Packard-Strasse 8

76337 Waldbronn, Germany

Warranty

The material contained in this

document is provided “as is,” and is

subject to being changed, without

notice, in future editions. Further, to the

maximum extent permitted by

applicable law, Agilent disclaims all

warranties, either express or implied,

with regard to this manual and any

information contained herein, including

but not limited to the implied

warranties of merchantability and

fitness for a particular purpose. Agilent

shall not be liable for errors or for

incidental or consequential damages in

connection with the furnishing, use, or

performance of this document or of

any information contained herein.

Should Agilent and the user have a

separate written agreement with

warranty terms covering the material in

this document that conflict with these

terms, the warranty terms in the

separate agreement shall control.

Technology Licenses

The hardware and/or software

described in this document are

furnished under a license and may be

used or copied only in accordance with

the terms of such license.

Restricted Rights Legend

U.S. Government Restricted Rights.

Software and technical data rights

granted to the federal government

include only those rights customarily

provided to end user customers.

Agilent provides this customary

commercial license in Software and

technical data pursuant to FAR 12.211

(Technical Data) and 12.212

(Computer Software) and, for the

Department of Defense, DFARS

252.227-7015 (Technical Data -

Commercial Items) and DFARS

227.7202-3 (Rights in Commercial

Computer Software or Computer

Software Documentation).

Safety Notices

A CAUTION notice denotes a hazard. It

calls attention to an operating

procedure, practice, or the like that, if

not correctly performed or adhered to,

could result in damage to the product

or loss of important data. Do not

proceed beyond a CAUTION notice

until the indicated conditions are fully

understood and met.

A WARNING notice denotes a hazard.

It calls attention to an operating

procedure, practice, or the like that, if

not correctly performed or adhered to,

could result in personal injury or

death. Do not proceed beyond a

WARNING notice until the indicated

conditions are fully understood and

met.

WARNING

CAUTION

Multi-Angle Light Scattering Detector User Manual 3

In this Guide….

This manual covers the Agilent 1260 Infinity II Multi-Angle Light Scattering Detector

(G7885A).

Please read this manual thoroughly before using the instrument!

Thank you for purchasing this detector from Agilent Technologies. You have

acquired a state-of-the-art instrument which enables you to perform unique

experiments and the characterization of the most complex particle, polymer and

protein samples.

This manual has been written for laboratory technicians who are responsible for

operation and maintenance of laboratory equipment. It is assumed that the user of

this manual is familiar with standard laboratory terminology. To ensure optimum

operation conditions, please read the manual completely and carefully before using

the detector. Use this product only in accordance with the guidelines and

instructions listed.

This manual describes in detail:

Characteristics

Operation and Maintenance

Important:

Do not use this instrument before completely understanding the full content of

this manual.

In the event that the instrument is loaned or transferred to a new owner please

ensure this manual is passed on with the device.

If this manual or any warning labels attached to the device become lost, get

damaged or are unreadable, promptly obtain replacement documents/ labels

from your nearest Agilent representative / distributor.

To ensure safe operation at any time, please read the safety instructions before

using the instrument.

In case of any uncertainty how to operate this detector, consult your Agilent

representative before starting to use this product.

NOTE Agilent offers basic, advanced and repeated trainings to support the user.

Multi-Angle Light Scattering Detector User Manual 4

Contents

1Introduction 6

After-Sales Service 7

Safety Instructions 8

Safety Symbols 16

Device Characteristics 17

2Operation 31

General Handling 32

Commissioning 35

User Interface 37

Changing the Solvent 39

Storage 40

Leak Detection 41

Vapor Detection 44

3Maintenance 46

Preventive Maintenance 47

Routine Maintenance 48

Detector Cleaning 49

4Troubleshooting 53

System Problems 54

Multi-Angle Light Scattering Detector User Manual 5

5Identified Cables 56

Cable and Connector Specifications 57

6Appendix 58

Waste Electrical and Electronic Equipment Directive 59

Agilent Technologies on Internet 60

Miscibility Chart of Solvents 61

Introduction

Multi-Angle Light Scattering Detector User Manual 6

1Introduction

After-Sales Service 7

Safety Instructions 8

Site Requirements 9

Power Considerations 10

Solvent Information 11

Using the Instrument 12

Maintaining the Instrument 13

Cleaning the Instrument 14

Handling Leak and Waste 14

Laser Warning 14

Static Electricity Warning 15

Safety Symbols 16

Device Characteristics 17

Delivery Content 17

General Purpose 17

Working Principle 18

Safety Functions 22

Physical Specifications 23

Performance Specifications 24

Detector Setup 26

Rear Side 28

Detection Angles 30

This chapter provides an overview of the principles and theory of Light Scattering

detection. Furthermore, the most important functions as well as specifications of

the detector are discussed.

Introduction

Multi-Angle Light Scattering Detector User Manual 7

After-Sales Service

If any problem occurs with this instrument, inspect it immediately and take

appropriate corrective action as described in chapter “Troubleshooting”on page 53.

If the problem persists or symptoms occur that are not described in this document,

disconnect the mains voltage and contact your Agilent representative.

Maintenance

Each component and the entire system should be checked periodically to ensure

that they function normally, otherwise the analysis data may not be precise and

reliable anymore. Typically, a yearly service is recommended.

Agilent offers special maintenance and service contracts to ensure maximum

lifetime and proper operation of the instrument during the entire life cycle. Before

shipment from the factory, this device was thoroughly inspected and tested.

The result of the inspection is documented in the attached protocol. Referring to

this protocol, please check the results of the hardware validation on a regular basis.

Introduction

Multi-Angle Light Scattering Detector User Manual 8

Safety Instructions

The user manual addresses persons who are qualified as chemical laboratory

technicians or have completed a comparable vocational training.

The following knowledge is required:

Fundamental understanding of liquid chromatography.

Familiarity with substances that are used for laboratory experiments.

Awareness regarding the health risks of chemicals.

Participation during a training by Agilent or an authorized person.

If you do not belong to this or a comparable professional group, you may not

perform the work described in this user manual under any circumstances. In this

case, please contact your superior.

The manufacturer does not warrant for any damage or injury resulting from

incorrect operation and maintenance, non-observance of the instructions in this

manual. Prior to delivery, this instrument has been tested for safe usage.

To ensure safe operation of the instrument, please read these safety

instructions carefully before use and follow them always while operating the

instrument.

Observe all of the Warning and Caution sections listed below. They are

extremely important for safety and to maintain a proper working device.

In this manual, Warning / Caution messages are always indicated using the

following conventions:

WARNING

A warning alerts you to situations that could cause physical injury or death.

Do not proceed beyond a warning until you have fully understood and met

the indicated conditions.

CAUTION A caution alerts you to situations that could cause loss of data, or damage of

equipment.

Do not proceed beyond a caution until you have fully understood and met the

indicated conditions.

Introduction

Multi-Angle Light Scattering Detector User Manual 9

Site Requirements

WARNING

•

Pay attention to the weight of the detectors. The detector weighs 16.5 kg

(36.4 lbs). Use proper lifting techniques to avoid potential injuries. Ensure

that you can handle the weight of the load.

•

Consider the entire weight of the combined system including all the

components. The lab table on which this detector is installed should be

sufficiently strong to support the total weight of the whole LC system. It

should be level, stable and have a depth of at least 600 mm. Otherwise, the

instrument could tip over or fall off the table.

•

Take measures to prevent the instrument from falling in the event of an

earthquake or other disaster. Strong vibrations could cause the detector to

fall over, resulting in injury and damage.

•

All other equipment connected to this instrument must be approved to an

appropriate safety standard and have reinforced insulation from the mains.

CAUTION

•

Avoid installation sites that are exposed to corrosive gases, strong vibrations, or

excessive dust. Otherwise, the performance and operability of the detector could

be impaired, and its lifetime may be shortened.

•Never place any liquid on top of the detector.

Bench Space

The module dimensions and weight (see Table “Physical Specifications”on page

23) allow you to place the module on almost any desk or laboratory bench. It needs

an additional 2.5 cm (1.0 inch) of space on either side and approximately 8 cm

(3.1 inches) in the rear for air circulation and electric connections.

If the bench shall carry a complete LC system, make sure that the bench is

designed to bear the weight of all modules.

NOTE The instrument is heavy and thus it is advisable to locate the system on a sturdy

bench.

NOTE Allow additional bench space for a PC if the instrument is to be computer-

controlled.

Introduction

Multi-Angle Light Scattering Detector User Manual 10

Power Considerations

WARNING

•

Ground the instrument.

To prevent electric shock in the event of an accident or electrical discharge,

the detector must be connected to protective earth. This is also important

to ensure stable operation and good data signals.

Ensure that all connected devices are grounded via the mains connector as

well.

•

Do not place heavy objects onto the power cord and keep any hot objects

away. This can damage the cord, resulting in fire, electrical shock, or

malfunction. If the cord is damaged, immediately unplug the mains power

cord and contact your Agilent representative.

•

Never modify the supplied power cord. Do not bend it excessively or pull on

it. Failure to do so could damage the cord, resulting in fire, electrical shock,

or malfunction.

•

Never replace the detachable power cord by an inadequately rated cord.

This can result in fire, electrical shock, or malfunction.

•

The power supply voltages and power consumption of this instrument are

listed in table “Physical Specifications”on page 23. Connect the detector

only to a power supply of the voltage indicated. Otherwise, fire or electric

shock may occur. Ensure that the power supply voltage is stable and has

sufficiently constant current capacity to operate all the components of the

system. If not, the detector will not operate at its rated performance levels.

•

If the power cord or its insulation gets damaged, unplug the cord and

contact your Agilent representative for a replacement cable immediately.

•

Only use mains connection cables admitted for use in your country. We

strongly recommend to only use cables supplied by Agilent.

•

In case of danger, immediately unplug the mains power cord either at the

wall power outlet, the power strip or on the rear of the devices.

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