Figure 2 Reagent and Buffer Compartments
AReagent compartment door—Encloses the reagent compartment with a latch under the lower-right
area of the door. The reagent compartment holds the reagent cartridge.
BReagent cartridge—The reagent cartridge is a prefilled single-use consumable.
CBuffer cartridge—The buffer cartridge is a prefilled single-use consumable.
DSpent reagents container—Spent reagents are collected for disposal after each run.
EBuffer compartment door—Encloses the buffer compartment with a latch under the lower-left corner of
the door.
Air Filter Compartment
The air filter compartment holds the air filter and is located in the back of the instrument. Replace the air
filter every 90 days. For information on replacing the filter, see
Replace Air Filter
on page 40.
Power Button
The power button on the front of the NextSeq 550Dx turns on power to the instrument and instrument
computer. The power button performs the following actions depending on the state of instrument power.
By default, the NextSeq 550Dx boots into diagnostic mode.
For information on initial power up of the instrument, see
Starting the Instrument
on page 19.
For information on shutting down the instrument, see
Shut Down the Instrument
on page 21.
Power State Action
Instrument power is off Briefly press the button to turn on the power.
Instrument power is on Briefly press the button to turn off the power. A dialog box appears on the screen to confirm
a normal instrument shutdown.
Instrument power is on Press and hold the power button for 10 seconds to cause a hard shutdown of the instrument
and instrument computer.
Use this method to turn off the instrument only if the instrument is unresponsive.
NOTE
Turning off the instrument during a sequencing run ends the run immediately. Ending a run is final. Run
consumables cannot be reused and sequencing data from the run is not saved.
Sequencing Consumables Overview
The sequencing consumables required to run the NextSeq 550Dx are provided separately in a single-use
kit. Each kit includes one flow cell, a reagent cartridge, a buffer cartridge, and library dilution buffer. For
more information, see the package insert
NextSeq 550Dx High Output Reagent Kit v2
.
Document # 1000000009513 v00
FOR IN VITRO DIAGNOSTIC USE
3
NextSeq 550Dx Instrument Reference Guide
