Qiagen DML 3000 Bedienungsanleitung

Sample & Assay Technologies

DML 3000 User Manual

For use with the

digene

ybrid Capture

2 DNA tests

5000-00031

QIAGEN

19300 Germantown Road

Germantown, MD 20874

U A

QIAGEN GmbH

QIAGEN trasse 1

40724 Hilden

GERMANY

L01052 Rev. 7

Trademarks: QIAGEN

digene

, Hybrid Capture

, Rapid Capture

(QIAGEN Group).

The LumiCheck Plate, its components, or its method of use may be covered by the following

patent and its international counterpart:

U. . Patent No. 6,335,997

Registered names, trademarks, etc. used in this document, even when not specifically marked as

such, are not to be considered unprotected by law.

Contents

DML 3000 User Manual Contents-1

Contents

1 Introduction 1-1

1.1 About this manual 1-1

1.2 General information 1-1

1.2.1 Technical assistance 1-1

1.2.2 Policy statement 1-1

1.3 Intended use of the instrument 1-1

1.3.1 Requirements for instrument users 1-2

2 Safety 2-1

2.1 Proper use 2-1

2.2 Electrical safety 2-3

2.3 Environment 2-3

2.4 Waste disposal 2-3

2.5 Biological safety 2-4

2.6 Chemical safety 2-4

2.7 Mechanical hazards 2-4

2.8 ymbols on the instrument 2-5

2.9 Additional symbols used in this user manual 2-6

3 Functional Description 3-1

3.1 LED status lights 3-3

3.2 Access door 3-4

3.3 Gas actuator lift arm 3-5

3.4 Optical sensor 3-6

3.5 Optical head 3-7

3.6 Plate carrier 3-8

3.7 Plate mask 3-9

3.8 Plate mask release latch 3-10

3.9 Microplate locator 3-10

3.10 Detector 3-12

3.10.1 Background signal 3-12

3.10.2 Efficiency 3-12

3.10.3 ensitivity 3-12

3.10.4 Dynamic range 3-12

3.10.5 Linearity 3-13

3.10.6 pectral response 3-13

Contents

Contents-2 DML 3000 User Manual

3.10.7 Understanding cross-talk 3-13

3.11 Transport locks 3-13

3.12 Power connection port and power switch 3-16

3.13 Power cord 3-17

3.14 Power adapter 3-18

3.15 U B-to- erial converter 3-18

4 Unpacking Procedures 4-1

5 Installation 5-1

5.1 Connecting the components 5-1

6 General Operation 6-1

6.1 Moving the transport locks to the home position 6-1

6.2 Placing a microplate in the DML 3000 6-2

6.3 ecuring the DML 3000 using the transport locks 6-4

6.4 Transporting the DML 3000 6-5

7 Maintenance 7-1

7.1 Cleaning the DML 3000 7-1

7.1.1 Cleaning the exterior of the DML 3000 7-1

7.1.2 Cleaning the interior of the DML 3000 7-1

7.2 Decontaminating the DML 3000 7-9

8 Troubleshooting 8-1

8.1 DML 3000 is not responding 8-1

8.2 “Communications Failed” message 8-1

8.3 “Door is Open” message 8-2

8.4 “Erratic Results” message 8-2

8.5 Rattling noise or “Mechanical Failure” message 8-2

8.6 Grinding noise or “Mechanical Failure” message 8-2

8.7 “Background too high, measurement cancelled” message 8-2

Technical Data A-1

DML 3000 Maintenance Log B-1

Waste Electrical and Electronic Equipment (WEEE) C-1

Contents

DML 3000 User Manual Contents-3

FCC Declaration D-1

Index Index-1

Contents

Contents-4 DML 3000 User Manual

This page intentionally left blank

Introduction

DML 3000 User Manual 1-1

1Introduction

Thank you for choosing the

digene

Microplate Luminometer (DML) 3000. We are

confident it will become an integral part of your laboratory.

Before using the instrument, it is essential that you read this user manual carefully

and pay particular attention to the safety information. The instructions and safety

information in the user manual must be followed to ensure safe operation of the

instrument and to maintain the instrument in a safe condition.

1.1 About this manual

This user manual provides instructions on using the DML 3000 to measure and

analyze specimens in conjunction with the

digene

HC2 ystem oftware. Use this user

manual along with the other user manuals provided as part of the

digene

HC2 ystem

uite.

1.2 General information

1.2.1 Technical assistance

At QIAGEN we pride ourselves on the quality and availability of our technical support.

If you have any questions or experience any difficulties regarding the instrument or

QIAGEN products in general, do not hesitate to contact us.

QIAGEN customers are a valuable source of information regarding our products. We

encourage you to contact us if you have any suggestions or feedback concerning our

products.

For technical assistance and more information, contact QIAGEN Technical ervices or

a local distributor (see back cover).

1.2.2 Policy statement

It is the policy of QIAGEN to improve products as new techniques and components

become available. QIAGEN reserves the right to change specifications at any time. In

an effort to produce useful and appropriate documentation, we appreciate your

comments on this user manual. Please contact QIAGEN Technical ervices.

1.3 Intended use of the instrument

The DML 3000 is intended to measure light that is emitted as a result of a

chemiluminescent reaction. Assay results obtained using chemiluminescence

technology in a 96-well microplates are calculated and interpreted according to assay

validation parameters.

Introduction

1-2 DML 3000 User Manual

1.3.1 Requirements for instrument users

The table below shows the level of training and experience required for

transportation, installation, use, maintenance, and servicing of the instrument.

Task Personnel Training and experience

Transportation Approved carrier Appropriately trained,

experienced, and approved by

QIAGEN

Installation Laboratory

technicians or

equivalent

Appropriately trained,

experienced, and familiar with the

use of computers and automation

in general

Routine use Laboratory

technicians or

equivalent

Appropriately trained,

experienced, and familiar with the

use of computers and automation

in general

Maintenance Laboratory

technicians or

equivalent

Appropriately trained,

experienced,

and familiar with the

use of computers and automation

in general

ervice QIAGEN Field

ervice employees

or personnel

trained by QIAGEN

Trained, certified, and authorized

by QIAGEN

Safety

DML 3000 User Manual 2-1

2Safety

This manual contains information about warnings and cautions that the user must

follow to safely operate the instrument and to maintain the instrument in a safe

condition.

WARNING

The term WARNING is used to inform you about situations that could result in

personal injury to you or other persons.

Details about these circumstances are given in a box like this one.

CAUTION

The term CAUTION is used to inform you about situations that could result in

damage to the instrument or other equipment.

Details about these circumstances are given in a box like this one.

Before using the instrument, it is essential to read this user manual carefully and to

pay particular attention to any instructions it contains concerning hazards that may

arise from the use of the instrument.

Note: Operators of this instrument must be trained in both general laboratory safety

practices and the safety requirements specific to the instrument. If the equipment is

used in a manner not specified by the manufacturer, the protection provided by the

equipment may be impaired.

The instructions given in this user manual are intended to supplement, not supersede,

the normal safety requirements prevailing in the user’s country.

2.1 Proper use

Maintain the instrument in good working order. If the instrument has been under

adverse conditions such as fire, flood, earthquake, etc., contact QIAGEN Technical

ervices.

WARNING/

CAUTION

Risk of personal injury and material damage.

Improper use of the DML 3000 may cause personal injuries to the user or damage

to the instrument.

The DML 3000 must only be operated by qualified personnel who have been

appropriately trained.

Safety

2-2 DML 3000 User Manual

WARNING

Risk of inaccurate test results

The access door must be completely closed during microplate measurement to

prevent ambient light from entering the DML 3000.

Ambient light could impact test results.

WARNING

Risk of personal injury

Before lifting the DML 3000, position yourself at the back of the DML 3000. The

weight distribution of the DML 3000 is heavier at the back than at the front.

To prevent injury, bend your knees and lift the DML 3000 slowly to compensate for

this weight difference.

WARNING

Risk of inaccurate test results

Failure to properly maintain the DML 3000 may cause high background, a

mechanical error, and/or irretrievable data loss. Make sure to perform the required

maintenance procedures.

CAUTION

Damage to the instrument

Insert the microplate in the DML 3000 so there is no interference from the

microplate locator. If necessary, lift the plate mask 90 degrees to make sure there is

no interference.

CAUTION

Damage to the instrument

If the internal components of the DML 3000 are not secured, severe damage to the

DML 3000 will result and the warranty will be voided.

CAUTION

Damage to the instrument

Do not use solvents or abrasive cleaners to clean the DML 3000.

CAUTION

Damage to the instrument

Do not touch the bottom surface of the optical head while removing the mask.

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