Agilent Technologies 7200 Bedienungsanleitung

Agilent Technologies

Agilent

7200 Accurate-Mass

Quadrupole

Time-of-Flight GC/MS

System

Operation Manual

Notices

No part of this manual may be reproduced in

any form or by any means (including elec-

tronic storage and retrieval or translation

into a foreign language) without prior agree-

ment and written consent from Agilent

Technologies, Inc. as governed by United

States and international copyright laws.

Manual Part Number

G3850-90008

Edition

First Edition, August 2014

Printed in USA

Agilent Technologies, Inc.

5301 Stevens Creek Blvd.

Santa Clara, CA 95051

Warranty

The material contained in this docu-

ment is provided “as is,” and is sub-

ject to being changed, without notice,

in future editions. Further, to the max-

imum extent permitted by applicable

law, Agilent disclaims all warranties,

either express or implied, with regard

to this manual and any information

contained herein, including but not

limited to the implied warranties of

merchantability and fitness for a par-

ticular purpose. Agilent shall not be

liable for errors or for incidental or

consequential damages in connec-

tion with the furnishing, use, or per-

formance of this document or of any

information contained herein. Should

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written agreement with warranty

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mercial Items) and DFARS 227.7202-3

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Safety Notices

CAUTION

A CAUTION notice denotes a haz-

ard. It calls attention to an operat-

ing procedure, practice, or the like

that, if not correctly performed or

adhered to, could result in damage

to the product or loss of important

data. Do not proceed beyond a

CAUTION notice until the indicated

conditions are fully understood and

met.

WARNING

A WARNING notice denotes a

hazard. It calls attention to an

operating procedure, practice, or

the like that, if not correctly per-

formed or adhered to, could result

in personal injury or death. Do not

proceed beyond a WARNING

notice until the indicated condi-

tions are fully understood and

met.

7200 Accurate-Mass QTOF Operation Manual 3

About This Manual

This manual contains information for operating and maintaining the Agilent

7200 Accurate-Mass Quadrupole Time-of-Flight GC/MS system.

1“Introduction”

Chapter 1 describes general information about the 7200 Q-TOF GC/MS,

including a hardware description, and general safety warnings.

2“Installing GC Columns”

Chapter 2 shows you how to prepare a capillary column for use with the MS,

install it in the GC oven, and connect it to the MS using the GC/MS interface.

3“Operating in Electron Impact (EI) Mode”

Chapter 3 describes routine operations in EI mode such as setting

temperatures, monitoring pressures, tuning, venting, and pumpdown.

4“Operating in Chemical Ionization (CI) Mode”

Chapter 4 describes additional tasks necessary to operate in CI mode.

5“Using the Removable Ion Source”

Chapter 5 shows you how to change the removable ion source.

6“General Maintenance”

Chapter 6 describes general maintenance procedures for the 7200 Q-TOF

GC/MS.

4 7200 Accurate-Mass QTOF Operation Manual

Hardware User Information

Accompanying your hardware and software is a comprehensive collection of

manuals, videos, user applications, and method development tools. These are

located on the:

To Install Your Hardware Library

Insert Disk 1 into your DVD drive and follow the prompts.

This can be installed by anyone who has authority to copy

information onto the receiving computer.

To Install Your Software Library

Insert the memory stick into a USB port and follow the prompts.

This can be installed by anyone who has authority to copy

information onto the receiving computer.

Allrights reserved.

Madein USA

Agilent Technologies

GC/GCMS Hardware User Manuals and Videos

Disk2/3

Toinstall:

1.Insert disk into DVD drive

2.Follow the instructions on the screen.

3.If autoplay is not enabled, double-click

"index_xx.html"on the DVD

where xx is:

enfor English

chfor中文

jpfor 日本語

VersionB.01.05

January,2013

Allrights reserved.

Madein USA

Agilent Technologies

GC/GCMS Hardware User Manuals and Videos

Disk2/3

Toinstall:

1.Insert disk into DVD drive

2.Follow the instructions on the screen.

3.If autoplay is not enabled, double-click

"index_xx.html"on the DVD

where xx is:

enfor English

chfor中文

jpfor 日本語

VersionB.01.05

January,2013

•Agilent GC and GC/MS User Manuals and Tools DVD set

•Agilent GC/MS Software Information and Manuals memory stick

See the Agilent 7200 Accurate Mass Q-TOF GC/MS System Quick Start

document (G6845-90014) for more details on how to install this information

on your computer.

7200 Accurate-Mass QTOF Operation Manual 5

Contents

1 Introduction

Abbreviations Used 10

The 7200 Accurate-Mass Quadrupole Time-of-Flight GC/MS

System 12

Hardware Description 14

Important Safety Warnings 15

Safety and Regulatory Certifications 18

Intended Use 21

Cleaning/Recycling the Product 21

Liquid Spills 21

Moving or Storing the MS 21

2 Installing GC Columns

Columns 24

To Install a Capillary Column in a Split/Splitless Inlet 26

To Condition a Capillary Column 29

To Install a Capillary Column in the GC/MS Interface 30

3 Operating in Electron Impact (EI) Mode

Operating the MS from the Data System 34

The GC/MS Interface 35

Before You Turn On the MS 37

Pumping Down 38

6 7200 Accurate-Mass QTOF Operation Manual

Controlling Temperatures 38

Controlling Column Flow 38

Controlling Collision Cell Flow 39

Venting the MS 39

Typical Vacuum Pressures in EI Mode 40

To Set Monitors for Temperature and Vacuum Status 41

To Set the MS Analyzer Temperature 43

To Set the GC/MS Interface Temperature from the MassHunter Workstation 45

To Calibrate the Column 46

To Configure the Collision Cell Gas 48

To Set the Collision Cell Gas Flow Rate 49

To Autotune the MS for EI Mode 50

To Remove the Upper RIS Cover 52

To Open the Analyzer Cover for Access to the Analyzer Sideplate 53

To Pump Down the MS 54

To Vent the MS 56

4 Operating in Chemical Ionization (CI) Mode

Setting Up Your MS to Operate in CI Mode 58

The GC/MS Interface 59

Operating the CI MS 61

High Vacuum Pressure in CI Mode 62

Other Reagent Gases 63

CI Autotune 65

The Flow Control Module 66

To Switch from the EI Mode to CI Mode 67

7200 Accurate-Mass QTOF Operation Manual 7

To Operate the Reagent Gas Flow Control Module 69

To Set a Reagent Gas Flow 71

To Perform a CI Autotune 72

5 Using the Removable Ion Source

The Removable Ion Source 76

To Change the Ion Source 78

To Install the RIS Probe Extraction Tool 80

To Remove the Source from the Analyzer Chamber 82

To Change the Ion Source on the RIS Probe Extraction Tool 84

To Install the Ion Source in the Analyzer Chamber 86

To Remove the RIS Probe Extraction Tool from the Instrument 87

6 General Maintenance

Before Starting 90

Maintaining the Vacuum System 94

Maintaining the Analyzer 95

To Disassemble the EI Ion Source 97

To Assemble the EI Ion Source 99

To Disassemble the CI Ion Source 101

To Assemble the CI Ion Source 103

To Clean the Ion Source 105

To Remove a Filament 109

To Install a Filament 111

8 7200 Accurate-Mass QTOF Operation Manual

Agilent 7200 Accurate-Mass Quadrupole Time-of-Flight GC/MS System

Operation Manual

Agilent Technologies

Introduction

Abbreviations Used 10

The 7200 Accurate-Mass Quadrupole Time-of-Flight GC/MS System 12

Hardware Description 14

Important Safety Warnings 15

Safety and Regulatory Certifications 18

Intended Use 21

Cleaning/Recycling the Product 21

Liquid Spills 21

Moving or Storing the MS 21

This section provides general information about the 7200 Accurate-Mass

Quadrupole Time-of-Flight (Q-TOF) GC/MS System, including a hardware

description, and general safety warnings.

10 7200 Accurate-Mass QTOF Operation Manual

1Introduction

Abbreviations Used

The abbreviations in Table 1 are used in discussing this product. They are

collected here for convenience.

Table 1 Abbreviations

Abbreviation Definition

AC Alternating current

ALS Automatic liquid sampler

BFB Bromofluorobenzene (calibrant)

CC Collision cell

CI Chemical ionization

DC Direct current

DFTPP Decafluorotriphenylphosphine (calibrant)

EI Electron impact

EPC Electronic pneumatic control

eV Electron volt

GC Gas chromatograph

id Inside diameter

LAN Local Area Network

m/z Mass to charge ratio

MFC Mass flow controller

MS Mass spectrometer

NCI Negative chemical ionization

OFN Octafluoronaphthalene (sample)

PCI Positive chemical ionization

PFDTD Perfluoro-5,8-dimethyl-3,6,9-trioxydodecane (calibrant)

PFET 2,4,6-tris (Pentafluoroethyl)-1,3,5-triazine

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