Agilent Technologies Enhancer Cell Bedienungsanleitung

Agilent Enhancer Cell

Operator’s Manual

Notices

Manual Part Number

70-9072 Rev B

February 2020

No part of this manual may be

reproduced in any form or by any means

(including electronic storage and retrieval

or translation into a foreign language)

without prior agreement and written

consent from Agilent Technologies, Inc.

as governed by United States and

international copyright laws.

Agilent Technologies, Inc.

3501 Stevens Creek Blvd.

Santa Clara, CA 95052 USA

Warranty

The material contained in this document

is provided “as is,” and is subject to being

changed, without notice, in future

editions. Further, to the maximum extent

permitted by applicable law, Agilent

disclaims all warranties, either express or

implied, with regard to this manual and

any information contained herein,

including but not limited to the implied

warranties of merchantability and fitness

for a particular purpose. Agilent shall not

be liable for errors or for incidental or

consequential damages in connection

with the furnishing, use, or performance

of this document or of any information

contained herein. Should Agilent and the

user have a separate written agreement

with warranty terms covering the

material in this document that conflict

with these terms, the warranty terms in

the separate agreement shall control.

Technology Licenses

The hardware and/or software described

in this document are furnished under a

license and may be used or copied only in

accordance with the terms of such

license.

Restricted Rights Legend

U.S. Government Restricted Rights.

Software and technical data rights

granted to the federal government

include only those rights customarily

provided to end user customers. Agilent

provides this customary commercial

license in Software and technical data

pursuant to FAR 12.211 (Technical Data)

and 12.212 (Computer Software) and, for

the Department of Defense, DFARS

252.227-7015 (Technical Data -

Commercial Items) and DFARS

227.7202-3 (Rights in Commercial

Computer Software or Computer

Software Documentation).

Safety Notices

CAUTION

A CAUTION notice denotes a

hazard. It calls attention to an

operating procedure, practice, or

the like that, if not correctly

performed or adhered to, could

result in damage to the product or

loss of important data. Do not

proceed beyond a CAUTION

notice until the indicated

conditions are fully understood

and met.

WARNING

A WARNING notice denotes a

hazard. It calls attention to an

operating procedure, practice, or

the like that, if not correctly

performed or adhered to, could

result in personal injury or death.

Do not proceed beyond a

WARNING notice until the

indicated conditions are fully

understood and met.

Enhancer Cell Operator’s Manual 3

Content

1 Introduction 5

Assembly Components 8

Unpacking Your Enhancer Cell Assembly 9

2 Operation 11

Membrane Selection Information for the Enhancer Cell 14

Ideal Characteristics for a Membrane 14

Examples of Membranes Used for In Vitro Release Tests 14

Content

4 Enhancer Cell Operator’s Manual

This page was intentionally left blank, except for this message.

Enhancer Cell Operator’s Manual 5

1Introduction

Assembly Components 8

Unpacking Your Enhancer Cell Assembly 9

1Introduction

6 Enhancer Cell Operator’s Manual

The Enhancer Cell Assembly, designed for research, quality control, and product

development laboratories, is a PTFE cell with adjustable volume and a screw cap

to retain the skin or artificial membrane. The assembly can be used with any

dissolution tester and is available with 4.0, 2.0, or 0.5 cm² surface area. Using the

Paddle-over-Enhancer-Cell method (see Figure 3, “Paddle over Enhancer Cell,” on

page 7) provides release rates comparable to Franz Cell technology. It provides

release rate data for quality control of topicals using readily available dissolution

apparatus, including 200 mL or standard 900 mL dissolution vessels.

The alignment tool (see Figure 1, “Enhancer Cell Assembly,” on page 6) is used to

hold the membrane in place and ensure the washer is centered properly while

using the adjustment tool to set the volume with the adjustment plate. When

purchasing more than one Enhancer Cell Assembly, one alignment tool is

required per size. The adjustment tool is universal and fits all sizes. Both the

alignment tool and the adjustment tool are required and must be ordered

separately. The Enhancer Cell Assembly does not include the vessel, paddle, or

membrane / skin.

Figure 1. Enhancer Cell Assembly

*not provided—for illustrative purposes only.

Retaining Ring

Washer

Membrane or Skin *

Adjustment Plate

with O-ring Cell Body R

Alignment Tool

Adjustment Tool

1Introduction

Enhancer Cell Operator’s Manual 7

Figure 2. Enhancer Cell Assembly Surface Areas

Figure 3. Paddle over Enhancer Cell

0.5 cm² 2 cm² 4 cm²

1Introduction

8 Enhancer Cell Operator’s Manual

Assembly Components

The Enhancer Cell Assembly consists of the following components (see

Figure 1, “Enhancer Cell Assembly,” on page 6):

•Retaining ring – secures the membrane or skin sample to the cell body and

ensures full contact with the sample.

•Washer – provides a leak-proof seal between the membrane, retaining ring,

and cell body.

•Membrane (not provided) – retains the sample in the sample

compartment. Usually an artificial membrane although some tests use

skin samples.

•Adjustment plate – allows control of the volume of the reservoir within the

cell body. This threaded part can be placed at the appropriate height for

each test and can be completely removed for easy cleaning. A Viton O-ring

prevents leakage.

•Cell body – provides a variable depth reservoir for the sample (semisolid,

solution, suspension, or emulsion) being tested.

Two additional tools are required to properly use the Enhancer Cell Assembly and

must be ordered separately:

•Adjustment tool – to move the adjustment plate.

•Alignment tool – to ensure the membrane is in proper contact with the

sample and the washer is properly centered.

This product is warranted to be free from manufacturing defects at the time of

delivery. Please report any problems upon receipt of merchandise to an Agilent

Customer Care Center. Contact information can be found www.agilent.com

under your country using the Contact Us link.

1Introduction

Enhancer Cell Operator’s Manual 9

Unpacking Your Enhancer Cell Assembly

1Carefully remove the Enhancer Cell Assembly.

2Ensure all of the following items were shipped with your Enhancer Cell:

If any item is damaged or missing, contact the Dissolution Systems Service

Department or your local Agilent representative for replacements.

•Enhancer Cell Assembly Operator’s Manual

•Retaining ring

•Washer

•Adjustment plate with O-ring

•Cell body

•Included if purchased separately:

•Adjustment tool

•Alignment tool

1Introduction

10 Enhancer Cell Operator’s Manual

This page was intentionally left blank, except for this message.

Inhaltsverzeichnis

Andere Agilent Technologies Laborausrüstung Handbücher

Agilent Technologies

Agilent Technologies 1141A Handbuch

Agilent Technologies

Agilent Technologies 7890A Handbuch

Agilent Technologies

Agilent Technologies 8511B Service-Handbuch

Agilent Technologies

Agilent Technologies 1260 Infinity Bedienungsanleitung

Agilent Technologies

Agilent Technologies Truevolt Series Service-Handbuch

Agilent Technologies

Agilent Technologies 6820 Bedienungsanleitung

Agilent Technologies

Agilent Technologies 55 AA Bedienungsanleitung

Agilent Technologies

Agilent Technologies 5975T LTM GC Bedienungsanleitung

Agilent Technologies

Agilent Technologies G5562A Einrichtungshandbuch

Agilent Technologies

Agilent Technologies 1200 Infinity Series Bedienungsanleitung

Agilent Technologies

Agilent Technologies 490 Micro GC Bedienungsanleitung

Agilent Technologies

Agilent Technologies 1220 Infinity II LC Series Bedienungsanleitung

Agilent Technologies

Agilent Technologies 1200 series Bedienungsanleitung

Agilent Technologies

Agilent Technologies 7890A Bedienungsanleitung

Agilent Technologies

Agilent Technologies Cary 8454 Bedienungsanleitung

Agilent Technologies

Agilent Technologies 4107 Bedienungsanleitung

Agilent Technologies

Agilent Technologies HS-16 Bedienungsanleitung

Agilent Technologies

Agilent Technologies 7820A Montageanleitung

Agilent Technologies

Agilent Technologies 6890 Series Bedienungsanleitung

Agilent Technologies

Agilent Technologies Intuvo 900 Benutzerhandbuch

Agilent Technologies

Agilent Technologies 4150 TapeStation system Benutzerhandbuch

Agilent Technologies

Agilent Technologies 7890A Betriebsanleitung

Agilent Technologies

Agilent Technologies 1260 Infinity Bedienungsanleitung

Agilent Technologies

Agilent Technologies 1100 Series Bedienungsanleitung

Beliebte Laborausrüstung Handbücher anderer Marken

Qiagen

Qiagen DML 3000 Bedienungsanleitung

Queensgate

Queensgate NANOSCAN OP400 Programmierhandbuch

Conviron

Conviron GEN1000-GE Bedienungsanleitung

Parr Instrument

Parr Instrument 4560 Bedienungsanleitung

IKA

IKA IC control Bedienungsanleitung

Integra

Integra DOSE IT Bedienungsanleitung

Endress+Hauser

Endress+Hauser Cleanfit CPA875 Bedienungsanleitung

NI PXI-5422 Handbuch

Collomix

Collomix Aqix Bedienungsanleitung

SPEX SamplePrep

SPEX SamplePrep 6875 Freezer/Mill Series Bedienungsanleitung

Ocean Insight

Ocean Insight FLAME-NIR+ Bedienungsanleitung

Parker

Parker ALIGN-MG-NA Bedienungsanleitung

BD 644787 Bedienungsanleitung

DENTAURUM

DENTAURUM Compact Megaplus Bedienungsanleitung

Biuged Laboratory Instruments

Biuged Laboratory Instruments BGD 626 Bedienungsanleitung

VWR

VWR SAS Super IAQ Bedienungsanleitung

illumina

illumina MiSeqDx Bedienungsanleitung

Yamato

Yamato BM510 Bedienungsanleitung